Cysteine-Rich Protein Prevents Weight Loss In Lung Cancer Patients: A Promising Intervention Study
Immunotec Inc. (TSX-V: IMM) announced the exultant extension of a
multi-center randomized, clone unsighted clinical make suffer by
cancer-related immensity prejudice (cachexia) surrounded by lung
cancer patients which be execute in column to hand pied Canadian
clinical centers(x). The research concluded that patients
dispensable with IMN 1207 show celebrated insertion in crumb
weight (Tozer et al. Antioxidants & Redox Signaling (2008)
10:395-402). Immunotec also announced the launching of a
follow-on research to conclude the cheery grades.
“Until in a microscopic, the treatment of idiopathic pulmonary
fibrosis has been predominantly ruthless on its inflammatory
entity. However, our findings stand for that lung tissue from
these patients does not exhibit a model inflammatory pattern. So,
these patients have need of to be manage in an entirely
investigational way,” said Dr. Kaminski.
Immunotec’s unknown study integrated 66 patients with advanced
lung cancer unloading fatherland of the art chemotherapy or
radiotherapy. The patients have already suffer significant
involuntary weight-loss prior to managing. During a six month
treatment irreversible prestige the patients be given any casein,
a protein plant minimal in cysteine which is widely previously
owned in clinical nutrition (”placebo”) or IMN 1207, a
specially-prepared glutathione enhancing cysteine-rich whey
protein isolate supplied by process of Immunotec Inc. The results
showed that patients in the placebo body of people unceasing to
omit weight whereas patients treated with IMN 1207 showed a
significant increase in body weight. Incidentally, these patients
also showed an increase in heart and quality of life parameter.
This study showed in aspiration of the hasty commonness that
cancer-related weight
loss (cachexia) can be prevented by a bachelor derivation of
protein. Dr. Gerald Batist, Chair, Department of Oncology, McGill
University stated “Having been entangled in the early mechanistic
study of the cathartic splurge of whey proteins, I’m over the
moon to see this focused formulation one tested in the clinic.
The facts to date blaze up and more or smaller quantity more and
expanded clinical trials”. Dr. Wulf Droge, Senior Vice-President
Research & Development at Immunotec Inc. stress that the
results of this first trial should be view with vigilant
optimism. A second trial have been initiate to confirm the
results.
Among other interview, this clinical trial also address the
controversy about antioxidant use in chemotherapy. Since
radiotherapy and heaps sort of chemotherapy donkey work by raise
even of oxidative stress and pithy payment harsh conception to
shatter cancer cell, oncologists have voiced contemplation that
treatment of the enduring with antioxidants may “protect” the
cancer from the venomous effects of the treatment. If this were
the knob, antioxidants could even be appointed to abbreviate the
life span of the patients. Immunotec’s study now showed that this
was unusually not the case with IMN 1207. Based on his until that
time work at his laboratory at the National Cancer Research
Center of Germany (DKFZ) in Heidelberg, Dr. Droge was justifiably
cheerful that supplementation with a grousing ancestor of the
through cellular antioxidant glutathione, would in reality boost
the fact of the patients, apparently by ameliorating adverse
effects of these therapy on the patients’ hearty tissues. The
results of this new study locate send on that this is true. The
antioxidant glutathione is certain from other antioxidants with
the grassroots antioxidant vitamins A, C, and E which be widely
used by the use of dietetic supplement. Glutathione is involved
in the slice open of reactive oxygen species and other
forthcoming toxic compound through better biochemical process and
can oust relatively illustrious and to your advantage
concentration in cells and tissues depending on the availability
of its biosynthetic precursor cysteine.
About IMN 1207 IMN 1207 is a cysteine-rich protein. It is the
research formulation of the undenatured whey protein
Immunocal(R)/HMS 90(R), a dietary crude fervour supplement,
manufacturing and market unanimous by Immunotec during the
long-gone 12 years. Immunocal(R)/HMS 90 is a precursor of the
major cellular antioxidant glutathione, an factor chief in
maintain a forceful immune net.
About Immunotec Inc.
Immunotec is engaged primarily in the encouragement and marketing
of natural health products, dietary supplements, silage, vitamins
and personal counsel products, many of which are manufactured on
its behalf by third party. Immunotec’s products are distributed
and sold in Canada and the United States through a framework
marketing system and in other country through selective
distributorship agreements. Immunotec’s domain here study is
another manifestation of its ongoing commitment to research and
development.
- (x) Montreal General Hospital (McGill University rule hospital)
Montreal, Quebec, Canada - (x) Cross Cancer Institute, Alberta
Cancer Board (University of Alberta affiliate) Edmonton, Alberta,
Canada - (x) Jewish General Hospital (McGill University teaching
hospital) Montreal, Quebec, Canada - (x) Juravinski Cancer Centre
(McMaster University and Hamilton Health Sciences affiliate)
Hamilton, Ontario,Canada.
- (x) Allan Blair Cancer Centre (a regiment of Saskatchewan
Cancer Foundation) Regina, Saskatchewan, Canada.
MMUNOTEC INC.
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